Survivin与子宫内膜癌的基因治疗的思考

子宫内膜癌是妇科常见的恶性肿瘤，发病机制不很清楚，早期诊断及治疗可改善预后，而目前的手术治疗方式损伤较大。Survivin是近年发现的新凋亡抑制基因，在多数恶性肿瘤组织中表达丰富，而在正常成人组织中不表达，这种表达特异性使其成为肿瘤诊断和基因治疗的新靶点。本文着重思考以Survivin为靶点的基因治疗方法在子宫内膜癌中的应用。

The Thoughts about Survivin and Gene Therapy of Endometrial Cancer

Endometrial cancer is a kind of common malignant cancer of women, and the pathogenesis is not very dear. The prognosis will be improved if with early diagnosis and therapy, but the modus operandi have a grave injury. Survivin is a new protein that suppresses apoptosis and a tumor- specific anti - apoptosis factor that is over-expressed selectively in all the most common human carcinomas, but not in normal adult tissues. Recently, survivin has been used as a novel therapeutic target for cancer. The article is to think about gene therapy of endometrial cancer when survivin is a target.