A prospective naturalistic study of the impact of an intensive medical treatment on the social behavior of child and adolescent cancer patients

The impact of intensive chemotherapy and prolonged hospitalization on the social behavior of child and adolescent cancer patients was assessed. Twenty-three patients, aged 18 months to 21 years, were observed while they received chemotherapy in a protected environment or in a regular hospital room. Single-subject analyses were used to examine changes on six behaviors in relation to changes in physiological status. Fourteen patients showed significant change in the frequency of at least one behavior. Play and sleep were the behaviors most likely to change. The changes began to occur as patients experienced the systemic toxic effects of the drugs, although a dissipation of drug toxicity generally was not accompanied by a corresponding behavior change. The findings are discussed in relation to age-developmental and interindividual heterogeneity in response to treatment.