| 前列腺素E2及其在肾脏调控中的作用 |
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| 引用本文： | 张莹,彭佑铭. 前列腺素E2及其在肾脏调控中的作用[J]. 医学与哲学(人文社会医学版), 2010, 0(8): 43-45 |
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| 作者姓名： | 张莹 彭佑铭 |
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| 作者单位： | 中南大学湘雅二医院肾内科,湖南长沙410011 |
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| 摘 要： | 前列腺素E2(PGE2)是最主要的前列腺素化合物,参与几乎所有的细胞代谢活动并介导多种不同的生理病理功能。PGE2的生物学效应是通过与不同的EP受体结合从而激活不同的信号转导通路来实现的。因为各类EP受体在肾脏的高分布,所以近来PGE2在肾脏中的作用日趋引起人们的重视。
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| 关 键 词： | 前列腺素E2 EP受体 肾脏 |
Prostaglandins E2 and Its Role in Renal Regulation |
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| Affiliation: | ZHANG Ying , PENG You - ming.( Xiangya the second Hospital, Central South University, Changsha 410011, China) |
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| Abstract: | PGE2 is a major prostaglandin, participating in almost all cellular metabolic activities, and mediating various physiopathological processes. PGE2 exerts its biological effect through binding to various EP receptors that result in activation of various signal transduction pathways. Due to the high abundance of these EP receptors in the kidney, the role of PGE2 in renal function is receiving more and more attention in recently years. This article will review the recent developments on PGE2 and its receptors, especially on their functions in renal regulation. |
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| Keywords: | prostagtandins E2 EP receptor renal |
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