Specifying the Neuropsychology of Affective Disorders: Clinical,Demographic and Neurobiological Factors |
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Authors: | Thomas Beblo Grant Sinnamon Bernhard T Baune |
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Institution: | (1) Department of Research, Evaluation and Documentation, Clinic of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Remterweg 69-71, 33617 Bielefeld, Germany;(2) Department of Psychology, University of Bielefeld, Bielefeld, Germany;(3) Department of Psychiatry, University of Adelaide, Adelaide, SA, 5005, Australia |
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Abstract: | Neuropsychological research in patients with affective disorders shows heterogeneous results with regard to the severity and
profile of cognitive impairments. In this paper we hypothesize that the investigation of clinical (subtypes, comorbidity,
traumatization, personality, severity, diurnal swings, course, duration, age of onset, biased processing, rumination, motivation,
experience of failure, sleep, suicidal tendencies, computer attitudes), demographic (age, education, gender) and neurobiological
factors (structural and functional brain changes, glucocorticoids, medication, ECT) that are related to cognitive performance
has specified the understanding of severity and profile of neuropsychological impairments. We reviewed the literature pertaining
to clinical, demographic and neurobiological factors following Pubmed and PsychInfo databases using different combinations
of general key-terms including “Affective Disorder,” “Depression,” “Mania,” “Neuropsychological,” “Neurobiological,” “Moderator,”
and “Review” as well as more specific demographic, clinical and neurobiological search terms. Findings from the literature
show that the consideration of these factors has improved knowledge about the severity of neuropsychological impairments in
patients with affective disorders whereas the neuropsychological profile is still poorly understood. Despite limited understanding,
however, the existent results provide promising suggestions for the development of treatment programs. |
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