Quantitative CT scan studies in aphasia. I. Infarct size and CT numbers |
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Authors: | M A Naeser R W Hayward S A Laughlin L M Zatz |
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Institution: | Boston University School of Medicine and Aphasia Research Center, Boston Veterans Administration Medical Center USA;Palo Alto Veterans Administration Medical Center and Stanford University School of Medicine USA;Palo Alto Veterans Administration Medical Center USA;Palo Alto Veterans Administration Medical Center and Stanford University School of Medicine USA |
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Abstract: | Infarct si?e (number of 1-mm2 pixels in the lesion) on CT scans of 30 aphasia patients was obtained with a semiautomated computer program. The mean number of lesion pixels present per slice containing lesion was approximately 500 for mild aphasias (transcortical motor and conduction), 700 for Wernicke's, 1000 for Broca's, 1500 for mixed, and 2000 for globals. These differences were significant for of the group pairwise comparisons. When lesion locus was controlled for in the anterior/posterior plane, 73–100% of the aphasia patients were correctly classified as to type of aphasia by a discriminant analysis utilizing only the number of lesion pixels present on two CT slices. Different slice combinations were used for different aphasia group comparisons. There was a significant correlation between severity of aphasia and lesion size. There was a significant correlation between lesion size and the CT numbers in the lesion. This type of analysis may be useful to predict the prognosis for recovery potential in aphasics who have CT scans performed at 2 months poststroke. |
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Keywords: | Address reprint requests to Dr M A Naeser V A Medical Center (116-B) 150 S Huntington Ave Boston MA 02130 |
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