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| 海洛因成瘾者的脑灰质密度下降 | |
| 引用本文： | 石金富,袁艺,邹枝玲,李祖贵,袁飞,张宝华,李静薇,沈模卫,翁旭初. 海洛因成瘾者的脑灰质密度下降[J]. 应用心理学, 2008, 14(2): 99-103 |
| 作者姓名： | 石金富 袁艺 邹枝玲 李祖贵 袁飞 张宝华 李静薇 沈模卫 翁旭初 |
| 作者单位： | 1. 中国科学院心理研究所,北京,100101;中国科学院研究生院,北京,100049 2. 西南大学,重庆,400715 3. 武警医学院附属医院,天津,300162 4. 天津市安康医院,天津,300240 5. 中国科学院心理研究所,北京,100101 6. 浙江大学心理与行为科学系,杭州,310028 |
| 基金项目： | 国家重点基础研究发展规划(973计划)，教育部哲学社会科学研究重大课题 |
| 摘 要： | 本研究对海洛因成瘾者（n=34）和无毒品依赖的正常被试（n=34）进行磁共振脑结构扫描，用基于体素的形态学测量（VBM）方法分析被试间灰质密度的差异，并考察了海洛因成瘾者用药时间与灰质密度之间的关系。结果表明，同正常对照组相比，海洛因成瘾者其额叶和颞叶下部的灰质密度显著下降。进一步分析显示，用药时间短于5年的成瘾者其灰质密度下降不明显，而用药时间5年以上的患者其灰质密度下降非常显著。本文讨论了上述结果的潜在临床价值和理论意义。 |
| 关 键 词： | 海洛因成瘾 灰质密度 用药年限 |
Decreased Gray Matter Density in Heroin Addicts |
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| SHI Jin-fu,YUAN Yi,ZOU Zhi-ling,LI Zu-gui,YUAN Fei,Zhang Bao-hua,LI Jing-wei,SHEN Mo-wei,WENG Xu-chu. Decreased Gray Matter Density in Heroin Addicts[J]. Chinese JOurnal of Applied Psychology, 2008, 14(2): 99-103 | |
| Authors: | SHI Jin-fu YUAN Yi ZOU Zhi-ling LI Zu-gui YUAN Fei Zhang Bao-hua LI Jing-wei SHEN Mo-wei WENG Xu-chu |
| Affiliation: | SHI Jin-fu1,2 YUAN Yi1,2 ZOU Zhi-ling3 LI Zu-gui4 YUAN Fei4Zhang Bao-hua5 LI Jing-wei1 SHEN Mo-wei6 WENG Xu-.chu1(1.Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,2.Graduate Universityof Chinese Academy of Sciences,Beijing 100049,3.Southwest University,Chongqing 400715,4.The Hospital of Medical College,Tianjin 300162,5.Tianjin Ankang Hospital,Tianjin 300240,6.Department of Psychology , Behavioral Sciences,Zhejiang University,Hangzhou 310028) |
| Abstract: | Thirty heroin addicts and 34 control participants were scanned with a 3T MRI scanner.Voxel-base Morphometry(VBM)was used to examine difference in grey matter density between the two groups.The heroin addicts were further divided into two groups according to years of drug usage,and were separately compared to the control group.Results showed that compared to the control group,the heroin addicts show decreased grey matter density in the frontal lobe and the temporal lobe.Further analysis revealed that only th... |
| Keywords: | heroin addiction gray matter density duration of drug use |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |