条件反射性免疫抑制研究的新进展

条件反射性免疫抑制 (CIS)模式基于巴甫洛夫条件反射的机理 ,通过大脑对免疫系统进行调节 ,是一种重要的心理神经免疫学方法。近 10年来的研究取得了一些重要的进展。首先 ,条件反射性免疫抑制模型已证实是非常稳定可靠的心理神经免疫模型。其次 ,关于CIS的机制在体液、细胞、神经学方面都有广泛的研究 ,而近年来更趋向于对神经性通路的探讨。而CIS的临床应用性研究也在实验动物身上取得了稳定可靠的结果 ,证实了其未来临床应用的可行性及潜力

ADVANCED PROGRESS OF CONDITIONED IMMUNOSUPPRESSION

There is accumulating evidence for a strong interaction between components of the nervous system and immune system. Little is known, however, how the interaction takes place. Because multiple changes are occurring simultaneously in all organ systems, it is fairly difficult to develop an approach that allows one to study the whole organism and define the mediators of the interacting systems. Conditioned immunosuppression, a phenomenon observed and confirmed in many laboratories, may provide insight into the pathways of communication between the brain and immune system. Conditioning allows one to separate the afferent from the efferent circuits. There is now a number of laboratory models of conditioned immunosuppression using a taste aversion paradigm. Experiments have shown that a number of immunological parameters can be modified by the behavioral conditioning. The mechanisms involved in conditioned immunosuppression have not been delineated. In recent years, many studies have demonstrated that removal of sympathetic noradrenergic input to the immune system can abrogate the decreased immune response induced by the behavioral conditioning and lesion into the insular cortex and amygdala can disrupt the acquisition of conditioned immunosuppression. Moreover, it has been observed that the survival of heart allografts in rats can be prolonged by conditioned immunosuppression paradigm. These experiments suggest that behaviorally conditioned immunosuppression may have important clinical implications as an adjunct to drug treatment in transplantation medicine.