伤害性躯体感觉的中枢网络动态编码过程

痛觉是感受躯体所受伤害性刺激的保护性感觉；慢性痛则是耗费巨额医疗费用的顽固性疾病。近年来的研究表明，疼痛感知觉的形成是一个大规模的中枢网络编码过程，包括了感觉、情绪、认知等若干不同的维度，牵涉到脊髓、脑干、边缘系统、皮层等多个相关结构。慢性痛则是一种由神经网络编码异常所导致的中枢性疾患。上述编码过程的任何异常都可能导致慢性痛。认识痛觉的中枢网络编码机制，将促进人们对感觉与情绪形成过程的深入理解，并有助于寻求新的临床疼痛治疗措施

Dynamic Coding of Nociceptive Somatosensory Information in Central Neuromatrix

Acute pain is a protective sensation that serves to warn us of impending harm. Chronic pain syndromes, on the other hand, are a group of resistant diseases consuming large amount of health care costs. Recent studies revealed that pain perception is formed via large-scale coding processes in central neural networks, involving several dimensions such as sensory, affective, and cognitive. Brain structures from spinal cord, brain stem, limbic system, to cortices are involved in these processes. Nevertheless, chronic painful diseases are suggested to be a result of some abnormal coding within this network. A thorough investigation of coding mechanism of pain within the central neuromatrix will give much insight into the mechanisms responsible for the development of chronic pain, hence helping lead to novel therapeutic interventions for pain management.