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The Relationship Between Blood Lead,Bone Lead and Child Intelligence
Authors:Gail A Wasserman  Pam Factor-Litvak  Xinhua Liu  Andrew C Todd  Jennie K Kline  Vesna Slavkovich
Abstract:We report associations between serial measures of blood lead and intelligence in children age 10–12 years, half heavily exposed to lead from the prenatal period onward, and half relatively unexposed. For a subsample, we examine bone lead-IQ associations, comparing them with blood lead associations. Both blood and bone lead levels were associated with intelligence decrements, small relative to the contribution of social factors. For each doubling of Tib-Pb, Full Scale, Performance, and Verbal IQ decreased by an estimated 5.5, 6.2, and 4.1 points, respectively. Bone lead-IQ associations were stronger than those for blood lead, which nonetheless provide robust analogues. Current BPb, easy to obtain, provides a useful means for assessing Pb exposure/IQ associations.
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