A genetic analysis of brain volumes and IQ in children |
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| Authors: | Marieke van Leeuwen Jiska S. Peper Stéphanie M. van den Berg Rachel M. Brouwer Hilleke E. Hulshoff Pol René S. Kahn Dorret I. Boomsma |
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| Affiliation: | 1. Department of Psychology, University of Minnesota, Minneapolis, MN 55455, United States;2. Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, United States;3. Center for Neurobehavioral Development, University of Minnesota, Minneapolis, MN 55455, United States;4. Department of Computer Science, University of Minnesota, Minneapolis, MN 55455, United States;5. Department of Child and Adolescent Psychiatry, Erasmus MC—Sophia Children''s Hospital, Rotterdam, The Netherlands;6. Department of Psychiatry, McLean Hospital/Harvard Medical School, Belmont, MA, 02478.;1. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23220, USA;2. Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA;3. Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA;4. Center for Behavioral Genomics Twin Research Laboratory, University of California, San Diego, La Jolla, CA 92093, USA;5. Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, 92093, CA USA;6. Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA 92093, USA;7. Department of Psychology, Boston University, Boston, MA 02215, USA;8. Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA;9. Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA;1. NHS Grampian, Aberdeen, United Kingdom;2. Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom;3. Department of Psychology, NUI, Galway, Ireland;4. Institute of Applied Health Sciences, University of Aberdeen, United Kingdom |
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| Abstract: | In a population-based sample of 112 nine-year old twin pairs, we investigated the association among total brain volume, gray matter and white matter volume, intelligence as assessed by the Raven IQ test, verbal comprehension, perceptual organization and perceptual speed as assessed by the Wechsler Intelligence Scale for Children-III. Phenotypic correlations between the brain volumes and intelligence traits ranged between .20 and .33. Processing speed and brain volume did not correlate. The relation between brain volume and intelligence was entirely explained by a common set of genes influencing both sets of phenotypes. |
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