This research examined a model of the stress response that includes cognitive-affective stress propensity, cognitive-affective processes, experienced affective reactions, subjective stress, and strain constructs. Using partial least squares analysis, this model was found to provide a good fit with the data. Moderated multiple regression analyses found support for the hypothesized moderating effects of individual stress propensity on the relationships of stressors with cognitive-affective processes. The research and practical implications of these findings are discussed.