Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI |
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Authors: | J.A. van Deursen E.F.P.M. Vuurman L.L. Smits F.R.J. Verhey W.J. Riedel |
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Affiliation: | aDept. of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands;bDept. of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, The Netherlands |
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Abstract: | BackgroundDecreased speed of information processing is a hallmark of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Recent studies suggest that response speed (RS) measures are very sensitive indicators of changes in longitudinal follow-up studies. Insight into the psycho-physiological underpinnings of slowed RS can be provided by measuring the associated event-related potentials (ERP).AimsThe current study aims to investigate the relation between RS and its psycho-physiological correlates in AD and MCI.MethodsFifteen psychoactive drug-naïve AD patients, 20 MCI patients and twenty age-matched, healthy control subjects participated. Response speed was measured during a simple (SRT) and choice reaction time task (CRT). An oddball and contingent negative variation (CNV) paradigm were used to elicit ERP. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment one week after the first.ResultsThe SRT and CRT distinguished the patient groups significantly. The P300 amplitude and latency also distinguished the groups and showed a significant correlation with response speed. The CNV amplitude did not reveal a significant difference between groups and also showed a low TRR.The TRR of the SRT, CRT and P300 amplitude and latency in general was moderate to high.The current study suggests that response speed measures on a behavioural and psycho-physiological level deserve attention as a possible marker in the diagnosis and follow-up of AD. |
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Keywords: | Alzheimer’ s disease Mild cognitive impairment Response speed Event related Potentials Contingent Negative Variation(CNV) P300 Aging |
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