Ambulatory accelerometry to quantify involuntary movements and tics in the syndrome of Gilles de la Tourette |
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| Authors: | Joke H M Tulen Wim H Groeneveld Judith H G J K Romers Sander J A de Vries and Ben J M van de Wetering |
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| Institution: | (1) Department of Clinical and Health Psychology, Utrecht University/Altrecht Academic Anxiety Outpatient Services, PO Box 80.140, 3508 TC Utrecht, The Netherlands;(2) Tourettes Clinic-Evelina Childrens Hospital at Guys and St. Thomas’, Kings Health Partners AHSC, London, UK;(3) Department of Child and Adolescent Psychiatry, University of Ulm, Ulm, Germany;(4) UK Tourette SyndromeAssociation, Department of Neurology, St George’s Hospital, London, UK;(5) Tourette SyndromeClinic, Great Ormond Street Hospital NHS Trust, London, UK;(6) Centre De R?f?rence National ‘Syndrome Gilles de la Tourette’, P?le des Maladies du Syst?me Nerveux, Groupe Hospitalier Piti?-Salp?tri?re, Assistance Publique des H?pitaux de Paris, Paris, France;(7) Centre de Recherche de l’Institut du Cerveau et de la Moelle ?pini?re (CRICM), UPMC Universit? Paris 6, Paris, France;(8) Department of Mental Health Sciences, UCL, London, UK;(9) Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy;(10) Department of Neurology, University Hospital Medical Centre, Hamburg, Germany;(11) Department of Child and Adolescent Neurology and Psychiatry, Catania University, Catania, Italy |
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| Abstract: | Gilles de la Tourette syndrome is a chronic neuropsychiatric disorder characterizedby recurrent and involuntary tics, in addition
to complex behavioral symptoms. Objective quantification of the nonspecific movements in Tourette patients can contribute
much to understanding the pathophysiology of this disease. We used three accelerometersto characterizehead movement patterns
and to objectively quantify head motility in the lateral, sagittal, and transversal planes in 9 Tourette patients and 14 controls
during periods of rest, conversation, and watching a videotape with an entertaining program. Characteristic head movement
patterns can be documented by means of accelerometry. Head motility levels in the lateral, sagittal, and transversal planes
were significantly higher in the patients than in the controls during all the procedures. The patients and the controls showed
a similar significant increase in head motility during conversation, but not during video watching. This first study shows
that for both standardized and ambulatory research, accelerometry may provide an objective tool by which to quantify the severity
and temporal dynamics of tics or nonspecific movements. |
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