Semantic impairment and anomia in Alzheimer's disease |
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| Authors: | F. Jacob Huff Suzanne Corkin John H. Growdon |
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| Affiliation: | 1. Massachusetts Institute of Technology, Massachusetts General Hospital, USA;2. Harvard Medical School USA;1. Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Science, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia;2. Department of Biology and Ecology, Faculty of Science, University of Novi Sad, Trg Dositeja Obradovića 2, 21000 Novi Sad, Serbia;3. Department of Physics, Faculty of Science, University of Novi Sad, Trg Dositeja Obradovića 4, 21000 Novi Sad, Serbia;4. First Department of Medicine, University of Szeged, Korányi fasor 8-10, H-6720 Szeged, Hungary;1. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center on Aging, Miami, FL;2. Wien Center for Alzheimer''s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL;3. Department of Neurology, University of Florida, Gainesville, FL;4. Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL;5. Department of Neurology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL;1. McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada;2. Douglas Hospital Research Centre, Montreal, QC, Canada;1. The Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia;2. Department of Clinical Neuropsychology, Austin Health, Heidelberg, Australia;3. Department of Neurology, Austin Health, Heidelberg, Australia;4. The Florey Department of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia;5. School of Psychological Sciences, University of Melbourne, Parkville, Australia;6. Department of Epileptology, University Hospital Bonn (UKB), Bonn, Germany;1. Netherlands Institute for the Study of Crime and Law Enforcement (NSCR), Amsterdam, The Netherlands;2. VU University Amsterdam, The Netherlands;1. Netherlands Interdisciplinary Demographic Institute, The Hague & University Medical Centre Groningen/University of Groningen;2. Vrije Universiteit, Amsterdam;1. Department of Neurology, First Affiliated Hospital, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China;2. National Key Laboratory of Diagnosis and Treatment for Infectious Diseases, First Affiliated Hospital, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China;3. Laboratory of Brain Medical Central, First Affiliated Hospital, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China |
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| Abstract: | Impairment in naming visually presented objects was investigated in patients with a clinical diagnosis of Alzheimer's disease. Impaired object naming correlated with difficulty listing the names of objects from a specified semantic category and with erroneous selection of words semantically related to the correct names for objects in a name recognition test. These results suggest that patients with Alzheimer's disease have a semantic impairment characterized by inability to distinguish among objects that are members of the same semantic category, and that this impairment is associated with difficulty producing the names for objects. Semantic impairment was present in patients with normal ability to discriminate visually presented shapes, indicating that the semantic deficit in Alzheimer's disease occurs independently of abnormalities of visuospatial function. Patients tended to make errors on the same items in both confrontation naming and name recognition tests, suggesting that the semantic impairment in Alzheimer's disease involves loss of information about specific objects and their names. |
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