Genotype modulates prenatal stress effects on aggression in male and female mice |
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| Authors: | C Kinsley B Svare |
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| Affiliation: | 1. Dept. Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands;2. Faculty of Social and Behavioural Sciences, Leiden University, Leiden, the Netherlands;3. Dept. of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands;4. Primary Care Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom;5. Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands;6. University of Groningen, University Medical Center Groningen, Groningen, the Netherlands |
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| Abstract: | Prenatal stress (heat and restraint) significantly increased postpartum aggression (proportion of animals fighting and/or the intensity of the behavior) in C57BL/6J female mice and reduced the behavior in DBA/2J females. For intermale aggression, prenatal stress increased the behavior (intensity of aggression) in C57BL/6J males but did not affect aggressive behavior in DBA/2J animals. Infanticidal behavior (the killing of young) exhibited by male mice was not influenced by prenatal stress in either strain. Relative anogenital distance measurements in neonates at birth did not serve as a reliable predictor of strain variation in prenatal stress effects. Prenatal stress did not influence this measure of prenatal androgen exposure in DBA/2J or C57BL/6J females. For males, prenatal stress elevated relative anogenital distance in C57BL/6J mice and decreased this measure in DBA/2J animals. Prenatal stress effects on aggressive behavior in male and female mice therefore depend upon genotype. Strain-dependent differences may be modulated by differences in endocrine reactivity to prenatal stress/and or differential central neural tissue sensitivity to hormones. |
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