Acute neuropsychological consequences of coronary artery bypass surgery |
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Authors: | Stanton Newman Peter Smith Tom Treasure Philip Joseph Peter Ell and Michael Harrison |
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Institution: | (1) University College and Middlesex School of Medicine, and the Middlesex Hospital, U.K.;(2) Academic Department of Psychiatry, University College and Middlesex School of Medicine, University of London, Mortimer Street, W1 London, U.K. |
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Abstract: | This study examines a series of coronary artery bypass patients (CABS) for neuropsychological and regional cerebral blood
flow (RCBF) changes at 8 days and 8 weeks post surgery. Seventy-three percent were found to have moderate or severe neuropsychological
deficits at 8 days post operation and 37% at 8 weeks post surgery. A comparison group of major vascular and thoracic surgery
patients was also found to have a significant proportion of neuropsychological deficit following surgery. The RCBF assessments
indicated a significant drop in mean RCBF at 8 days post surgery in the coronary artery bypass group which did not persist
to 8 weeks. The comparison group showed no changes in RCBF following surgery. The findings suggest different patterns of recovery
and origins of the neuropsychological deficit in the two groups and emphasize the need for appropriate control groups in studies
examining the cortical effects of extracorporeal circulation.
In addition, the project received generous support from the special trustees of the Middlesex Hospital. |
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Keywords: | |
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