The clinical utility of the auditory P300 latency subcomponent event-related potential in preclinical diagnosis of patients with mild cognitive impairment and Alzheimer’s disease |
| |
| Institution: | 1. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy;2. Hospital San Raffaele Cassino, Cassino (FR), Italy;3. Oasi Research Institute - IRCCS, Troina, Italy;4. IRCCS SDN, Napoli, Italy;5. Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy;6. Clinica Neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy;7. Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI), Università di Genova, Genova, Italy;8. Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy;9. Neuromed: IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed Pozzilli, Isernia, Italy;10. Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d''Annunzio of Chieti-Pescara, Chieti, Italy;11. IRCCS San Raffaele Pisana, Rome, Italy;12. Universitätsspital Basel, Abteilung Neurophysiologie, Basel, Switzerland;13. Department of Neurology 2, Med Campus III, Faculty of Medicine, Johannes Kepler University, Kepler University Hospital, Linz, Austria;14. Department of Old Age Psychiatry, King''s College University, London, UK;15. Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy;p. Laboratory of Alzheimer''s Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy;q. Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy;r. Department of Biophysics, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey;s. Department of Neurology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey;t. Department of Neurosciences and Department of Neurology, Dokuz Eylül University Medical School, Izmir, Turkey;u. Department of Psychology and Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey;v. Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy;w. Institute of Neuroscience, Newcastle University, Newcastle, UK;x. Department of Neurology, Institute of Memory and Alzheimer''s Disease (IM2A), Brain and Spine Institute (ICM), Paris, France;y. Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland;1. Department of Neurology, Xiangya Hospital, Central South University, PR China;2. Department of Neurology, Luoyang Central Hospital Affiliated to Zhengzhou University, PR China;1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, USA;2. Department of Biostatistics, Virginia Commonwealth University, USA;3. Hunter Holmes McGuire VA Medical Center, USA;4. Department of Psychiatry & Behavioral Sciences, University of Minnesota, USA;5. Department of Psychology, University of Minnesota, USA;6. Minneapolis VA Health Care System, USA;7. Departments of Psychiatry and Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, USA;1. Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey;2. Department of Psychology, Dokuz Eylul University, Izmir, Turkey;3. Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland;4. Istanbul Medipol University, Vocational School, Program of Electroneurophysiology, Istanbul, Turkey;5. Istanbul Medipol University, Graduate School of Health Sciences, Department of Neuroscience, Istanbul, Turkey;6. Istanbul Medipol University, International School of Medicine, Department of Biophysics, Istanbul, Turkey;7. REMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey;8. Istanbul Medipol University, School of Medicine, Department of Neurology, Istanbul, Turkey;9. Dokuz Eylul University Medical School, Department of Neurology, Izmir, Turkey;10. Dokuz Eylul University, Brain Dynamics Multidisciplinary Research Center, Izmir, Turkey |
| |
| Abstract: | The present meta-analysis investigated the clinical utility of the auditory P300 latency event-related potential in differentiating patients with Alzheimer’s disease (AD), patients with mild cognitive impairment (MCI), and unaffected controls. Effect size estimates were computed from mean P300 latency measurements at midline electrodes between patients and unaffected controls using the random effects restricted maximum likelihood model. The effects of clinical and ERP/EEG methological variables were assessed in a moderator analysis. P300 latency was found to be significantly prolonged in patients with AD (and MCI) compared to unaffected controls. Shortened P300 latencies were observed when comparing patients with MCI to patients with AD. Clinically relevant differences in P300 latency effect sizes were associated with mean age, interstimulus interval, stimulus difference, target frequency, reference electrode, and sampling rate. The meta-analytic findings provide robust statistical evidence for the use of the auditory P300 latency subcomponent as a biological marker of prodromal AD. |
| |
| Keywords: | P300 latency Event-related potential Alzheimer’s disease Mild cognitive impairment Biological marker |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
