Changes in Pediatric Health-Related Quality of Life in Cystic Fibrosis After IV Antibiotic Treatment for Pulmonary Exacerbations |
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| Authors: | Avani C. Modi Crystal S. Lim Kimberly A. Driscoll Carrie Piazza-Waggoner Alexandra L. Quittner Jamie Wooldridge |
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| Affiliation: | (1) Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA;(2) Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA;(3) Department of Medical Humanities and Social Sciences, Florida State University-College of Medicine, Tallahassee, FL, USA;(4) Departments of Psychology and Pediatrics, University of Miami, Coral Gables, FL, USA;(5) Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Adherence and Self Management, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave. -MLC 7039, Cincinnati, OH, USA |
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| Abstract: | Intravenous (IV) antibiotic therapy for pulmonary exacerbations (PE) has been shown to improve pulmonary functioning for patients with cystic fibrosis (CF); however, little is known about its effects on pediatric health-related quality of life (HRQOL). This prospective study assessed the impact of IV treatment of a PE on generic and CF-specific HRQOL for children and adolescents with CF. Participants included 52 children and adolescents with CF experiencing a PE (M age = 13.6 years; 54% males; MtextFEV1% M_{{{text{FEV}}_{1% } }} predicted = 58.8%). HRQOL, pulmonary functioning, and body mass index were assessed before and after IV antibiotic treatment. Results of this prospective, observational study indicated significant improvements on CFQ-R Respiratory (M change score = 11.7; 95% CI = 6.3–17.1; p < .0001) and Weight (M change score = 15.9; 95% CI = 7.9–23.8; p < .0001) scales. The CF-specific measure was more sensitive to changes in HRQOL than the generic instrument. These data suggest that CF-specific HRQOL improves with treatment for a PE with IV antibiotics. The noted statistically and clinically significant changes in the CFQ-respiratory scale indicate that the measure may be beneficial to pulmonary health care teams. |
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