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Serum calcium levels in Alzheimer's disease: A finding and an aetiological hypothesis
Affiliation:1. Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China;2. Shandong Xinchuang Biotechnology Co., LTD, Jinan 250102, China;3. Shandong Laboratory Animal Center, Jinan 250002, China;1. Department of Neurosurgery, Graduate School of Medicine, Ehime University, Japan;2. Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Japan;3. Department of Regeneration of Community Medicine, Graduate School of Medicine, Ehime University, Japan;4. Center for Advanced Research and Education, Asahikawa Medical University, Japan;5. Department of Legal Medicine, Graduate School of Medicine/Faculty of Medicine, Osaka University, Japan;1. Department of Neurology, Johns Hopkins University School of Medicine, United States;2. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, United States
Abstract:We report that lower serum Ca2+ levels are found in severely demented patients when compared with mildly affected individuals (P < 0.001) and we formulate an aetiological hypothesis of Alzheimer's disease based on the disruption of intraneuronal microtubular networks by low calcium levels and other forms of intraneuronal mechanical disruption. The findings are discussed in relation to Hendrickson's theory of the biological basis of psychometric intelligence.
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