应当重视肿瘤微环境中外因的研究

长期以来，肿瘤学的几乎所有研究一直在关注肿瘤细胞本身，从哲学角度看这无疑是正确的。肿瘤细胞是肿瘤事件发生发展的内因。近年研究表明，肿瘤的外因，即肿瘤微环境中的非肿瘤细胞及其产物，对肿瘤的发生发展起着十分重要的作用。肿瘤微环境的外因，通过作用于内因选择了更具抵抗性的肿瘤细胞，促进了肿瘤的进展与转移。因此，重视肿瘤微环境的外因研究，对肿瘤治疗学将会开辟以外因为靶点干预的新思路。

To Pay Extra Attention to the Study on Extrinsic Factors in the Tumor Microenvironment

So far, almost all the researches on tumor pathogenesis has been focused on the tumor cell itself. Tumor cell is intrinsic factor in the tumor events. However, recent studies indicated that non--tumor cells and their products, i. e. , extrinsic factors in the tumor microenvironment, played very important role in the tumor initiation and progression. Many studies showed that extrinsic factors in the tumor microenvironment enable a tumor cell resistant to therapy and promote cancer cell progression and metastasis. Therefore, it is necessary to pay much attention to the research on the extrinsic factors in the tumor microenvironment, and we believe that it will provide new insights into tumor target therapy in the future.