Treadmill Gait Analysis Characterizes Gait Alterations in Parkinson's Disease and Amyotrophic Lateral Sclerosis Mouse Models |
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Authors: | Thomas G. Hampton Ivo Amende |
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Affiliation: | 1. Mouse Specifics, Inc. , Boston, Massachusetts;2. Caritas St. Elizabeth's Medical Center , Tufts University , Boston, Massachusetts |
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Abstract: | The effect of anxiety on learning and performance of a complex motor task was determined. In addition the effects of two stressors—competition and failure—and the interactions between these stressors and anxiety were investigated. 40 high and 40 low anxiety Ss (selected by the Taylor Manifest Anxiety Scale) learned and performed a coincident timing task. Competition was presented by offering the Ss a monetary reward for the best performance, while failure was manipulated by giving false knowledge of results and indicating that the performance level was inferior. Results showed that Ss low in anxiety performed significantly better than Ss high in anxiety during the initial learning of a complex motor task. No difference was found between Ss extreme in anxiety once the task was well-learned. Competition and failure did not affect performance or interact with the anxiety level of Ss. |
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Keywords: | amyotrophic lateral sclerosis gait MPTP Parkinson's disease SOD1 G93A |
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