Role of the striatal cholinergic system in the regulation of learned manipulation in rats

The experiments were performed on adult Wistar male rats trained to push with the forepaw on a fixed piston inside a narrow tube. It was found that after localized intracerebral injection of a cholinergic antagonist into the dorso-lateral (but not medial) neostriatum (i.e., the caudato-putamen) the behavioral performance requiring brief innate movements remained unchanged, but the performance requiring a prolonged pushing movement (> 50 msec) became disrupted. Microinjection of carbacholine (0.03-3 μ g/1 μ1) did not affect the performance of the acquired movements, whereas scopolamine (3 μ g/1 μ1) led to the significant decrease in pushing time. We conclude that changes in the state of the dorso-lateral neostriatal cholinergic system result only in disturbances of the sensory-controlled component of a complex instrumental movement. The 1994 Pavlovian Society Young Investigator Awardee was Nadezda Dubrovskaya, first author of this paper, which was presented at the annual meeting of the Pavlovian Society, July 3, 1994, in Prague, Czech Republic.