首页 | 本学科首页   官方微博 | 高级检索  
     


High calcium intake does not prevent stress-salt hypertension in dogs
Authors:David E. Anderson Ph.D.  Pamela Murphy B.S.  William Kearns M.A.
Affiliation:1. Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, 12901 North 30th Street, 33612, Tampa, Florida
2. J. A. Haley Veterans Administration Hospital, Tampa, Florida
Abstract:Avoidance conditioning sessions and isotonic saline (1.3 L/day) were administered to dogs for 12 days under conditions of a low (0.1%) or high (1.5%) calcium diet. Twenty-four-hour mean arterial pressure increased comparably during the stress-salt conditioning periods on both the low (systolic: +16 ± 5 mm Hg; diastolic: +6 ± 2 mm Hg) and high (systolic: +17 ± 4 mm Hg; diastolic: +11 ± 4 mm Hg) calcium diets. Urine volume, sodium excretion, and serum calcium levels on the high calcium diet were not significantly different from those on the low calcium diet. In a second experiment, calcium was infused continuously for six days into the arterial circulation of normotensive or stress-salt hypertensive dogs at a rate of 0.12–0.23 mEq/min. Although serum calcium levels increased by up to 50% under these conditions, there were no significant effects on 24-hour levels of arterial pressure. In contrast to the protective effect of augmented potassium intake, these findings indicate that calcium intake does not influence the development of stress-salt hypertension in dogs.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号