Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis |
| |
| Authors: | J Cobb Scott Steven Paul Woods Georg E Matt Rachel A Meyer Robert K Heaton J Hampton Atkinson Igor Grant |
| |
| Institution: | (1) Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA 92120, USA;(2) Department of Psychiatry (0847), School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA;(3) Department of Psychology, San Diego State University, San Diego, CA 92182, USA;(4) HIV Neurobehavioral Research Center, Department of Psychiatry (0847), University of California, San Diego, 150 West Washington Street, 2nd floor, San Diego, CA 92103, USA |
| |
| Abstract: | This review provides a critical analysis of the central nervous system effects of acute and chronic methamphetamine (MA) use,
which is linked to numerous adverse psychosocial, neuropsychiatric, and medical problems. A meta-analysis of the neuropsychological
effects of MA abuse/dependence revealed broadly medium effect sizes, showing deficits in episodic memory, executive functions,
information processing speed, motor skills, language, and visuoconstructional abilities. The neuropsychological deficits associated
with MA abuse/dependence are interpreted with regard to their possible neural mechanisms, most notably MA-associated frontostriatal
neurotoxicity. In addition, potential explanatory factors are considered, including demographics (e.g., gender), MA use characteristics
(e.g., duration of abstinence), and the influence of common psychiatric (e.g., other substance-related disorders) and neuromedical
(e.g., HIV infection) comorbidities. Finally, these findings are discussed with respect to their potential contribution to
the clinical management of persons with MA abuse/dependence. |
| |
| Keywords: | Central nervous system Methamphetamine Abuse Dependence Neuropsychological assessment Cognition |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
