Direct observation and automated scoring of the activity of active and inactive inbred mouse strains |
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Authors: | Charles L. Goodrick |
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Affiliation: | 1. Gerontology Research Center, National Institute of Child Health and Human Development, 20014, Baltimore, Maryland
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Abstract: | Inbred mouse strains previously found to be low (A/J) and high (C57BL/6J) in open-field activity were tested in a plastic oval runway while their runway activity was directly observed and also monitored by a contact switch recording device. The activity of active C57BL/6J mice was accurately monitored by the recording device, but scores of inactive A/J mice were inflated by a factor between 2 and 3 X. Activity differences between strains were consistently maintained[during repeated tests under both high and very dim illumination if direct observational scores were used. Utilization of scores obtained by the automated recording device resulted in a failure to obtain group differences under the condition of dim illumination. These results were directly related to the mode of locomotion of the two mouse strains. |
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