Maternal depressive history, teen 5HTTLPR genotype, and the processing of emotional faces: Exploring mechanisms of risk |
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| Authors: | Jacobs Rachel H Pine Daniel S Schoeny Michael E Henry David B Gollan Jackie K Moy Gregory Cook Edwin H Wakschlag Lauren S |
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| Institution: | aColumbia University and New York State Psychiatry Institute, 1051 Riverside Drive Unit 74, New York, NY 10032, United States;bNational Institutes of Mental Health, NIMH, 15K North Drive, MSC-2670, Bethesda, MD 20892, United States;cChapin Hall at the University of Chicago, 1313 E. 60th St. Chicago, IL 60637, United States;dInstitute for Health Research and Policy, University of Illinois at Chicago, 1747 W. Roosevelt Road, Chicago, IL 60608, United States;eNorthwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, 446 E. Ontario, Suite 7-100, Chicago, IL 60601, United States;fNorthwestern University Feinberg School of Medicine, Department of Medical Social Sciences, 710 N. Lake Shore Drive, Abbott Hall, Suite 729, Chicago, IL 60611, United States;gInstitute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, 1747 W. Roosevelt Road, Chicago, IL 60608, United States |
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| Abstract: | Variations in the serotonin transporter gene (5HTTLPR) and biased processing of face-emotion displays both have been implicated in the transmission of depression risk, but little is known about developmental influences on these relationships. Within a community sample of adolescents, we examine whether 5HTTLPR genotype moderates the link between maternal depressive history and errors in face-emotion labeling. When controlling for current levels of depression and anxiety among youth, a two-way interaction between maternal depressive history and 5HTTLPR genotype was detected. Specifically, adolescents whose mothers reported a depressive history and who had a low expressing genotype made more errors in classifying emotional faces when compared with adolescents with an intermediate or high expressing genotype, with or without maternal depression history. These findings highlight the complex manner in which maternal depression and genetic risk may interact to predict individual differences in social information processing. |
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| Keywords: | Intergenerational transmission Depression 5HT Adolescence Face processing G X E |
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