高压氧对老年小鼠记忆力及脑内Ca~(2+)的影响

观察常压（１０１．３ｋＰａ）及高压（２５３．３ｋＰａ）吸氧处理后老年小鼠学习记忆的改善情况，并测定４个主要脑区（皮层，海马，小脑，间脑）突触体内钙离子浓度，结果表明，常压及高压吸氧可明显增强老年小鼠在新异的自我活动能力，并且显著提高记忆保持力，对衰老引起的脑内高下现象具有明显的抑制效应，其中２５３．３ｋＰａ高压氧降钙效果更明显，脑内高钙与记忆衰退密切相关，提示高压氧可能是通过降钙作用而改善脑老化而

THE EFFECT OF HYPERBARIC OXYGENATION MEMORY ABILITY AND ON BRAIN SYNAPTOSOME Ca~(2 ) IN AGED-MICE

The spontaneous behavior and the learning memory retention of aged-mice were assessed using open field and one-trial passive avoidance task after atmospheric (101.3kPa)oxygen or hyperbaric (253.3kPa)oxygen treatment (HBOT),At the same time, the synaptosomal free calcium concentration in some main brain regions (cerebral probe Ca2 ],indicat or Fura-2/AM and an AR-CM-MIC cation measurement system The results showed that the spontaneous behavior and explorative response in the openfield significantly increased and the memory retention was remarkably elevated. The high synaptosomal free Ca2 concentration caused by decrepit was decreased afteratmospheric oxygen or HBOT, and there was a better inhibiting action of HBOT on high level of calcium in the brain, Memory declination was closely related with hypercalcemic phenomenon in the brain. It indicated that the senile memory impediment can be treated by HBOT through decreasing the synaptosomal free Ca2 concentration.