评价和控制药物不良反应的认识与思考

用科学的世界观和方法论指导药物不良反应的评价和控制。从药物不良反应的发生机制、临床表现、因果关系的判定原则出发,与马克思主义哲学的基本观点相结合,提出了几点认识和思考。药物治疗作用与副作用既对立又统一;药物治疗效应向毒性反应的转变是量变到质变的过程;药物过敏反应的发生是内因外因相互作用的结果;药物与不良反应联系强度的判定必须符合前因后果性;药物与不良反应联系强度的判定必须排除混杂因素的干扰,找到内在的、本质的联系。

The Realization and Thinking in Assessment and Control of Adverse Drug Reactions

To guide adverse drug reactions assessment and control with scientific world outlook and methodology.Combine with the fundamental view of Marxist philosophy, analysis the mechanisms, symptoms and causality judging rules of adverse drug reactions. A few view and thought are put forward.Drug treatment effect and side effect display unity of opposites. Drug threatment effect divert to toxic reaction demonstrate a course of quantity to qualitative change. Drug allergy is a mutual effect of internal and external cause. The judgement of connection intensity of drug and adverse reactions must conform to the role of previous cause and after effect. As connection intensity of drug and and adverse reactions is judged, the confuse factor disturbance must be removed and the internal and essential connection.must be probed.