Perinatal linoleate deprivation impairs learning and memory in adult rats |
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| Authors: | H L Rüthrich P Hoffmann H Matthies W F?rster |
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| Affiliation: | 1. Department of Translational Neurosciences, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands;2. Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 11, SE-405 30 Gothenburg, Sweden;3. Danone Nutricia Research, Utrecht, the Netherlands;4. Department of Pediatrics, University Medical Centre Groningen, Groningen, the Netherlands;5. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands;6. Karakter Child and Adolescent Psychiatry, Nijmegen, the Netherlands;7. Department of Anatomy & Neuroscience and APC Microbiome Ireland, University College Cork, Ireland;8. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;9. Suzanne Higgs School of Psychology, University of Birmingham, Birmingham, UK;1. Department of Physiological Sciences, Londrina State University, Londrina, PR, Brazil;2. Department of General Pathology, Londrina State University, Londrina, PR, Brazil;3. Department of Structural and Functional Biology, Botucatu Biosciences Institute, São Paulo State University, SP, Brazil;1. Food Science and Tecnology Program, Federal University of Paraíba, João Pessoa, Brazil;2. Department of Nutrition, Federal University of Campina Grande, Cuité, Brazil;3. Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, CAV-Federal University of Pernambuco, Recife, Brazil;4. Department of Nutrition, Federal University of Pernambuco, Recife, Brazil |
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| Abstract: | Rats receiving polyunsaturated fatty acid (PUFA) deficient diets during the perinatal period showed in adult age undisturbed acquisition of a footshock motivated brightness discrimination task, but a significant impairment of retention. The same effects on retention were obtained in rats receiving the PUFA deficient diet in adulthood, when the behavioral parameters were investigated at the end of the dietary treatment. |
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