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Strategies for resolving the heterogeneity of schizophrenics and their relatives using cognitive measures
Authors:L J Chapman  J P Chapman
Abstract:The resolution of the heterogeneity of schizophrenics and their relatives using cognitive tasks requires measures of individual differences--usually of differential ability, which is inferred from differential performance. Tasks that are suited for establishing a group's differential ability are often unsuited for measuring individual differences. The problem is that for any group for which Tasks A and B have different mean accuracy, the (A - B) difference scores of individual subjects have an artifactual curvilinear relation to (A + B) overall accuracy, with the largest (A - B) scores occurring at about 50% (A + B) overall accuracy for a dichotomously scored free-response task. Two possible solutions are (a) to convert Task B scores to residualized scores, using the regression of Task B scores on Task A scores as determined for normal subjects; or (b) to titrate overall (A + B) accuracy of each subject to a constant level by manipulating a variable.
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