An animal model of the hyperactive-child syndrome suitable for the study of the effects of food additives

This report describes the use of an animal model for testing the relationship between the effects of ingesting food additives and hyperactivity. Telomian × beagle hybrid dogs were chosen as subjects because this breed has been observed to exhibit behavior seen as analogous to the hyperactivity of children. Two studies were conducted by adding or deleting butylated hydroxyanisole and Food, Drug, and Cosmetic red dye number 40 to the diet of each dog. A test of sitting was performed to measure the level of activity. While a relationship was not observed between the ingestion of the additive and the level of activity, several issues pertaining to the use of the animal model became apparent. These issues and the use of animals for future research in this area are discussed.