Acquisition, extinction and reacquisition of a conditioned response in the cockroach: The effects of orotic acid

Cockroaches can be trained to keep their metathoracic leg out of a saline solution. Isolated metathoracic ganglia learnt faster than headless animals, which in turn learnt faster than intact animals. Extinction took longer in the isolated ganglion than in the other two preparations. Extinction times increased with increasing dose of orotic acid, a precursor of RNA. Orotic acid did not systematically affect the times for acquisition and reacquisition of the learnt response.