Neonatal auditory evoked responses are related to perinatal maternal anxiety |
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| Affiliation: | 1. Laureate Institute for Brain Research, Tulsa, OK;2. Janssen Pharmaceuticals, Beerse, Belgium;3. Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden;4. Haskins Laboratories, New Haven, CT;5. Stanford University, Stanford, CA;6. Merrill Palmer Skillman Institute for Child and Family Development, Wayne State University, Detroit;7. Scientific and Statistical Computing Core, National Institute of Mental Health, Bethesda, MD;1. Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;2. University of Toronto, Canada;3. Ottawa Hospital Research Institute, Ottawa, ON, Canada;4. University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada;5. Carleton University, Ottawa, ON, Canada;1. Psychiatry, Sydney Medical School at Westmead Hospital, Sydney, Australia;2. Brain Dynamics Centre, The Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead, Sydney, Australia;3. Psychology, Stanford University, CA, United States;4. Psychiatry and Behavioural Science, Stanford University, CA, United States;5. VA Palo Alto (Sierra-Pacific MIRECC), CA, United States;1. FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland;2. Turku University Hospital and University of Turku, Department of Child Psychiatry, Turku, Finland;3. Satakunta Hospital District, Psychiatric Care Division, Harjavalta, Finland;4. Department of Community Dentistry, Institute of Dentistry, University of Turku, Turku, Finland;5. University of Turku and Turku University Hospital, Department of Psychiatry, Turku, Finland |
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| Abstract: | Maternal stress and anxiety during pregnancy are related to negative developmental outcomes for offspring, both physiological and psychological, from the fetal period through early adolescence. This robust relationship is likely to be partly explained by alterations in fetal neurodevelopmental programming, calling for further examination of neurophysiologically-based cognitive markers that may be related to the altered structure–function relationships that contribute to these negative developmental outcomes. The current investigation examined the relationship between perinatal maternal anxiety and neonatal auditory evoked responses (AERs) to mother and stranger voices. Results indicated that neonates of low-anxiety mothers displayed more negative frontal slow wave amplitudes in response to their mother’s voice compared to a female stranger’s voice, while neonates of high-anxiety mothers showed the opposite pattern. These findings suggest that neonates of perinatally anxious mothers may demonstrate neurophysiologically-based differences in attentional allocation. This could represent one pathway to the negative psychological outcomes seen throughout development in offspring of anxious mothers. |
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