Ovarian steroids and cognitive function

The ovarian steroids, estrogen and progesterone, not only govern reproductive events in mammalian females but also influence an array of other processes. Of particular clinical interest is the potential of ovarian steroids to facilitate storage of new memories and to protect neurons from various threats. Research during the past decade confirms that estrogen and progesterone influence the biochemical, electrical, and structural properties of neurons in brain regions that subserve learning and memory. These mechanisms form the biological foundations for the complex effects of ovarian steroids on cognitive functions in various species, including humans. Despite significant progress in our understanding of the roles of hormonal factors in cognitive function and neuronal survival, the value of hormone replacement as a treatment and deterrent for cognitive impairments associated with age, disease, and injury remains uncertain as we enter the new century.