Competition between two memory traces for long-term recognition memory |
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| Authors: | Engelmann Mario |
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| Affiliation: | 1. Behavioral Neuroscience Program, Department of Psychology, Binghamton University—SUNY, Binghamton, NY 13902-6000, United States;2. Department of Psychology & Neuroscience, University of Colorado, Boulder, CO 80309-0345, United States;1. Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90033, USA;2. Department of Integrative Anatomical Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA;3. Department of Pharmaceutical Biosciences, Uppsala University, Sweden |
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| Abstract: | Previous studies investigating the processes which underlie memory consolidation focused almost exclusively on isolated learning events. Here I studied the competition of two similar memory traces for consolidation non-conditioned recognition memory in adult male C57BL/6JOlaHsd mice using the olfactory cues based social discrimination procedure. My results show that the interference phenomena that cause forgetting are time-dependent, and that retroactive interference can be discriminated from proactive interference. Furthermore, both types of interference can be suppressed by subcutaneous anisomycin treatment immediately after presentation of the interference stimulus. These findings imply that interference phenomena, which result from the competition of two similar memory traces for long-term recognition memory, are related to the progress of memory consolidation and linked to protein synthesis. |
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