The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning |
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Authors: | Clark L Cools R Robbins T W |
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Affiliation: | Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK. lc260@cam.ac.uk |
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Abstract: | Converging evidence from human lesion, animal lesion, and human functional neuroimaging studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-making and reversal learning. The ascending 5-HT and dopamine neurotransmitter systems have a modulatory role in both processes. There is accumulating evidence that measures of decision-making and reversal learning may be useful as functional markers of ventral prefrontal cortex integrity in psychiatric and neurological disorders. Whilst existing measures of decision-making may have superior sensitivity, reversal learning may offer superior selectivity, particularly within prefrontal cortex. Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning. |
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