Pharmacotherapy of schizophrenia and affective disorders: Behavioral assessment of psychiatric medications

Objectively defined, publicly observable ward behaviors (body activity, extremity activity, scanning, social interaction, proximity, participation, laughing/smiling, and idiosyncratic behavior) emitted by psychiatric inpatients with either schizophrenic or affective disorders were time sampled both before and during the administration of psychiatric medications (neuroleptics, tricyclics, and lithium). The data indicate that the primary effects of the pharmacological interventions are confined to activity measures and symptoms rather than social behaviors. The implications of these results for treatment protocols are discussed in terms of interactions between pharmacological and psychosocial interventions. In addition, rates of behavior during treatment were related to baseline rates via a log-log function of negative slope, a result that is consistent with data derived from the infrahuman laboratories. Taken together the results provide support for attempts to relate preclinical and clinical psychopharmacology and suggest that behavioral assessment can be applied profitably to drug effects in clinical situations.These investigations were supported in part by State of Illinois Department of Mental Health and Developmental Disabilities Grants RD836-13 and RD622-02 to the first author. The cooperation of the Illinois State Psychiatric Institute staff is gratefully acknowledged. Assistance in data collection was provided by S. Sussman and K. Mueser.