Genetic Risk,Perceived Risk,and Cancer Worry in Daughters of Breast Cancer Patients |
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Authors: | Email author" target="_blank">John?M?QuillinEmail author Joann?N?Bodurtha Donna?McClish Diane?Baer?Wilson |
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Institution: | (1) Department of Human & Molecular Genetics and Massey Cancer Center, Virginia Commonwealth University, 1101 E. Marshall St, Richmond, VA 23298-0033, USA;(2) Department of Biostatistics and Massey Cancer Center, Virginia Commonwealth University, P.O. Box 980032, Richmond, VA 23298-0032, USA;(3) Department of Quality Medicine and Massey Cancer Center, Virginia Commonwealth University, P.O. Box 980036, Richmond, VA 23298-0036, USA |
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Abstract: | This study explored relationships between worry, perceived risk for breast cancer, consulting a genetic counselor, having
genetic testing, and genetic risk for women whose mothers had breast cancer. Analyses involved data from a community-based
phone survey of women whose mothers had breast cancer. Participants were categorized as having low, intermediate, or high
genetic risk based on their reported family history, in accordance with an accepted classification scheme. The Lerman Breast
Cancer Worry Scale measured worry, and participants reported their perceived lifetime likelihood of breast cancer, risk compared
to others, and chance from 1 to 100. ANOVA, chi-square, and multiple regression analyses were conducted as appropriate. One
hundred-fifty women participated. Mean age was 38 years, and 81% were Caucasian. Fifty-two women had low, 74 had intermediate,
and 24 had high genetic risk for breast cancer. There were no significant differences in worry or perceived risk by hereditary
risk category. Most high-risk women (91%) had not spoken with a genetic counselor, and no one had previous genetic testing.
These findings suggest perceived risk, worry about breast cancer, and use of expert consultation do not match the genetic
contribution to risk. There is a need for effectively stratifying and communicating risk in the community and providing tailored
reassurance or referral for high-risk assessment. |
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