The influence of dibutyryl cyclic cmp on aggression in the mouse

Cytidine 3′,5′-cyclic monophosphate (cCMP) and its associated enzymes have recently been identified in a number of mammalian tissues. The analogy with other cyclic nucleotides leads to speculation that it may prove to be a second messenger for some neurotransmitters and/or hormones. In this study we examined the possibility that cCMP may modulate aggressive behaviour. When dibutyryl cCMP (250 μg and 2.5 mg/k SC) was administered to mice it proved to have a potent antiaggressive influence but had little effect on general activity. It was concluded that cCMP may prove to have an important metabolic function.