| Abstract: | Mice that are confined in a narrow cylinder readily bite inanimate targets. The following studies were conducted to determine the effects of tail shock on the target biting behavior of two strains of mice. During 20-min daily sessions, ten tail shocks were administered on a fixed-time 2-min schedule. One group of mice received a tone-conditioned stimulus (CS) which terminated with the onset of the shock, and a second group of mice did not. Target bites were collected in eight 15-sec bins over the 2-min trial and cumulated over the session. It was observed that tail shock was followed by an increase in target biting and that there was a comparatively high intershock interval biting rate. In addition, intershock interval biting was suppressed for the duration of the CS. These observations are discussed in terms of the utility of this paradigm for the psychopharmacological assessment of aggressive behavior. |
