Hypertonic saline mimics the effects of vasopressin on inhibitory avoidance in the rat |
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Authors: | C Lebrun M Le Moal R Dantzer F E Bloom G F Koob |
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Institution: | 1. Division of Preclinical Neuroscience and Endocrinology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, California 92037, USA;2. Laboratoire de Psychobiologie des Comportements Adaptatifs INSERM U.259, Université Bordeaux II Domaine de Carreire,- rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France |
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Abstract: | Rats tested in a step-through inhibitory avoidance task were administered hypertonic saline (2 ml of 0.25. 0.5, and 1.0 M intraperitoneally) or arginine vasopressin (1.0, 2.0, and 4.0 micrograms) injected subcutaneously (sc) after the training trial where the rats received a mild footshock (0.2 mA, 3 s). Both hypertonic saline and vasopressin produced significant increases in latency to reenter 24 h later. These treatments failed to increase reentry latencies in animals that received the same procedure but no shock. The facilitation of inhibitory avoidance produced by hypertonic saline was reversed by sc administration of 25 micrograms of the vasopressor (V-1) vasopressin antagonist, dPtyr(Me)AVP. The results suggest that the endogenous release of vasopressin can be behaviorally significant in situations of acute homeostatic challenge. |
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