Some acute effects of d-lysergic acid diethylamide on the rat

There is a wealth of literature available on the psychosis-like effects of very small doses of d-lysergic acid diethylamide (LSD-25) in human subjects. It is reported that the drug produces profound changes in emotional behaviour, feelings of depersonalization, visual and auditory hallucinations, catharsis-like episodes and slight changes in autonomic nervous system activity.

The present experiment investigates the possibility of relating the behavioural disturbances induced by LSD-25 to known physiological data. Variation in the latency and running times of trained albino rats is examined. It is demonstrated that latency scores are directly affected by the cerebral concentration of the drug; and that sensory thresholds appear to be raised. It is further shown that when the level of stimulation is raised the rats appear to behave normally.