多囊卵巢综合征与代谢综合征

高胰岛素血症和高雄激素血症是多囊卵巢综合征（PCOS）的两大基本特征，共同参与了PCOS的发生与发展，胰岛素抵抗是连接PCOS和MS的纽带。本文阐述了PCOS和MS的相互重叠、PCOS产生胰岛素抵抗的机制、胰岛素抵抗对PCOS的作用。指出早期识别PCOS，有利于及时纠正、阻断其内分泌紊乱，防止MS的发生。提高胰岛素敏感性的治疗措施包括生活方式调整和药物治疗，生活方式的调整主要是控制饮食、运动和改变生活方式，包括戒烟、戒酒；药物治疗主要是使用二甲双胍和噻唑烷二酮类药物，其他药物如右旋肌醇、N-乙酰半胱氨酸、生长抑素类似物、α糖苷酶抑制剂、内腓肽受体抑制剂也具有增强胰岛素敏感性的作用。

Polycystic Ovary Syndrome and Metabolic Syndrome

Hyperinsulinemia and hyperandrogenism is the basic characteristics of polycystic ovary syndrome （PCOS） , which took part in the occurrence and development of PCOS. Insulin resistance is a link between PCOS and MS. Mutual overlap of PCOS and MS, mechanism of insulin resistance in PCOS and role of insulin resistance on the PCOS were expounded in this paper. The early identification of PCOS is conducive to timely correct and block its endocrine disorders for preventing the occurrence of MS. The treatment measures of improve insulin sensitivity include lifestyle adjustments and medication. Lifestyle adjustment is controlled diet, exercise and lifestyle changes, including quitting smoking and alcohol. Drug therapy is the use of metformin and thiazolidinediones drugs, other drugs such as D-inositol, N -- acetyl--L--cysteine, somatostatin analogues, a glucosidase inhibitors, EP receptor inhibitors also enhance the role of insulin sensitivity.