| 用ROC评价AFP、VEGF和瘦素对HCC的诊断价值 |
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| 引用本文： | 侯振江,周秀艳,闫金辉,陈俊荣,戴殿禄. 用ROC评价AFP、VEGF和瘦素对HCC的诊断价值[J]. 医学与哲学(人文社会医学版), 2008, 29(4): 17-19 |
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| 作者姓名： | 侯振江 周秀艳 闫金辉 陈俊荣 戴殿禄 |
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| 作者单位： | [1]沧州医学高等专科学校,河北沧州061001 [2]唐山市工人医院,河北唐山063000 [3]沧州市中心医院,河北沧州061000 |
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| 基金项目： | 河北省科学技术发展和规划项目“肝癌患者血清瘦素和血管内皮生长因子的相关性研究”,项目编号：052761288 |
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| 摘 要： | 用受试者工作特性曲线（ROC）对184例HCC患者和73例健康对照者的血清AFP、VEGF、Lep及三者联合检测结果进行评价。结果显示：AFP、VEGF、Lep测定结果在两组资料间比较均有统计学意义（P〈0．01）。HCC患者的AFP、VEGF、Lep与三者联合检测在ROC曲线下面积分别为0．902、0．841、0．712和0．952。AFP、VEGF、Lep对HCC的临床诊断临界点分别为25ug／L、25lng／L和15ug／L。因此，AFP、VEGF、Lep三者联合检测可显著提高对HCC诊断的灵敏度和有效性，优于AFP、VEGF、Lep的单项检测。
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| 关 键 词： | ROC曲线 肝细胞癌 甲胎蛋白 血管内皮生长因子 瘦素 |
Application of ROC Curve in the Analysis and Evaluation of the Diagnostic Value of the Combined Detection of AFP,VEGF and Lep in Hepatocellular Carcinoma |
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| Affiliation: | HOU Zhen -jiang,ZHOU Xiu -Yan,YAN Jin --hui,et al( Cangzhou Medical College ,Cangzhou 061001 ,China) |
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| Abstract: | To analyse the detection results of AFP,VEGF and Lep , and the combined detection AFP, VEGF and Lep from 184 H CC patients and 73 healthy controls,ROC curve was employed. AFP, VEGF and Lep were significantly different between groups （P〈0.01）. The area under ROC curve of AFP ,VEGF, Lep and the three joint detection in HCC were 0. 902,0. 841,0. 712, respectively and 0. 952, respectively. The clinical diagnostic critical point of AFP, VEGF and Lep in HCC were 25μg/L, 25 lng/L, 15μg/L. The combined detection of AFP, VEGF and Lep is better than AFP , VEGF or Lep individual detection. |
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| Keywords: | ROC curve hepatocellular carcinoma alpha fetoprotein vascular endothelial growth factor leptin |
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