The effects of physostigmine during the acquisition of avoidance behaviour as a function of the intersession interval

Rats were trained and tested on an avoidance task in a shuttle box. The change in the performance of the control rats over two sessions was found to be a U-shaped function of the interval between the sessions. The change in performance of rats injected with physostigmine prior to the second session was also found to be a U-shaped function of the intersession interval, although the drug was shown to impair avoidance behaviour. These results are consistent with those of Hamburg (1967) and of Biederman (1970), and support the general contention that cholinergic mechanisms in the brain are involved in the control of avoidance and escape behaviour in the rat. They do not, however, necessarily support the hypothesis advanced by Deutsch (1969, 1971) to describe a biochemical basis of learning and memory, especially if it is used to explain the effects of cholinesterase inhibitors on avoidance behaviour in the shurtlebox.