亲代孕前成瘾药物暴露对子代行为的影响及其表观遗传机制

孕前成瘾药物暴露不仅危害使用者的身体健康,而且会对子代的生理行为造成影响,近年来研究发现表观遗传机制在其中发挥重要作用。孕前成瘾药物暴露会对子代的成瘾易感性和焦虑样行为造成影响,引起子代的抑郁样行为和认知受损。这些现象可能是成瘾药物通过引起亲代生殖细胞内表观遗传修饰变化所致,其中包括印记基因、神经递质系统、BDNF三个方面的表观遗传修饰变化。此外,未来除了加强以上三个方面基因的研究,也需要增加其他方面基因的研究,以及寻找能预测子代异常行为的表观遗传生物标志物。

The impact of the parental preconception exposure to addictive drugs on the offsprings' behavior and the epigenetic mechanism

Parental preconception exposure to addictive drugs influences not only parents themselves,but also their offsprings' physiological function and behavior.In recent years,research shows that the epigenetic alterations play a vital role in abnormal behavior.Parental preconception exposure to addictive drugs influences the offsprings' susceptibility to drug addiction and anxiety-like behavior,induces offsprings' depression-like behavior and cognitive impairment.Epigenetic alterations in germ cells induced by preconception exposure to addictive drugs contribute to the onset of offsprings' abnormal behavior through the changes of imprinted gene,BDNF,and neurotransmitter system.Future studies,besides strengthening the above three aspects research,should pay attention to other aspects of genes and to try to find the epigenetic biomarker in germ cells for the prediction of the offsprings' abnormal behavior.