Affiliation: | (1) Department of Medicine, Division of Gastroenterology and Endocrinology, Georg-August-Universität, Göttingen, FRG;(2) Medizinische Universitätsklinik, Robert-Koch-Strasse 40, W-3400 Goettingen, FRG; |
Abstract: | Many studies have shown that developmental cocaine exposure alters brain function and behavior; the present study examined the relationship between brain metabolism and behavioral responses to drug challenge. SKF 82958, a selective D1 dopamine agonist, was administered to preweaning cocaine-exposed (50 mg/kg/day) rats and controls at 60 days of age. Deoxyglucose was administered 30 min later, during the peak behavioral response, to measure brain functional activity Pearson product-moment correlations of behavior (locomotor activity and Stereotypic behavior) with rates of glucose metabolism in components of the nigrostriatal and mesolimbic circuits were analyzed. The analysis revealed that under saline-challenge conditions in control animals, rates of metabolism in mesolimbic regions are positively correlated to rates of locomotor activity, whereas in cocaine-treated rats, these correlations were absent. Following SKF challenge, a different pattern was seen; locomotor activity or Stereotypic behavior was not correlated with mesolimbic or nigrostriatal metabolism, respectively,in controls but was positively correlatedin cocaine-treatedrats. Therefore, cocaine exposure during development enhances the coupling of metabolism in components of the mesolimbic and nigrostriatal dopamine systems with the behavioral output associated with these systems under drug-challenge conditions. This may be due to loss of inhibitory influences within the mesolimbic and nigrostriatal systems. Thus, the correlation of behavior and cerebral glucose metabolism provides a unique way of examining the effect of developmental cocaine exposure. |