Effects of pentobarbital sodium anesthesia and neurohumoral agents on the cardiac orienting reflex |
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Authors: | Harry A. Teitelbaum Joseph E. O. Newton W. Horsley Gantt |
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Affiliation: | 1. The Pavlovian Laboratory, Johns Hopkins University School of Medicine, Baltimore, Md. 2. Neuropsychiatric Research Laboratory, Veterans Administration Hospital, North Little Rock, Arkansas 3. Pavlovian Lab., Veterans Administration Hospital, Perry Point, Md.
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Abstract: | Studies of the cardiac orienting reflex in 16 dogs, moderately anesthetized and awake are reported. In the anesthetized dogs prominent transient heart rate decrease was commonly noted within one or two beats after the onset of various auditory stimuli, and less often after visual stimuli. This cardiac inhibition was neither as prominent nor as frequent in occurrence in awake dogs. The respiratory cycle at stimulus onset influenced the appearance and degree of heart rate decrease, with the greatest and most frequent decreases occurring during the expiratory phase. Atropine abolished the response. There was little evidence of habituation of this orienting response under anesthesia, although “waxing” and “waning” apparently related to minute-by-minute fluctuations in degree of unconsciousness, occurred. These findings are discussed in relation to neurophysiological and neuroanatomical correlates of orienting responses, hypotheses of orienting and attention and cardiovascular neurohumoral mediators. |
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