Factors Influencing Men's Interest in Gene Testing for Prostate Cancer Susceptibility |
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Authors: | Duane D. Culler Judy Silberg Lauren Vanner-Nicely Joy L. Ware Colleen Jackson-Cook Joann Bodurtha |
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Affiliation: | (1) Center for Human Genetics, University Hospitals of Cleveland, Cleveland, Ohio;(2) Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia;(3) Department of Pathology, Virginia Commonwealth University, Richmond, Virginia |
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Abstract: | Interest in genetic testing for inherited cancer susceptibility is high in the general population. Women at risk for BRCA1 and BRCA2 mutations represent the best-studied population undergoing genetic testing for cancer susceptibility. However, it is unclear whether factors influencing interest in genetic testing in women are directly applicable to men. We designed a study to examine factors associated with men's interest in genetic testing to identify prostate cancer susceptibility. Our sample consisted of 267 men present in waiting rooms of a urology clinic in an urban area. We examined whether the concept of monitoring could be used to predict the interest of men in a genetic test for prostate cancer susceptibility. Our results indicated that monitoring trait was positively associated with interest in genetic testing in these men, but principally for patients rather than nonpatients. Moreover we found that monitoring was associated with over estimation of risk in those men with prostate cancer. Other factors found to influence interest in genetic testing included recommendation by a doctor, family history of prostate cancer, and cost. This study indicated that interest in genetic testing and estimation of risk is influenced by a complex interaction between both psychological factors (monitoring) and nonbehavioral factors (such as patient status, cost, and doctor recommendation). |
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Keywords: | monitoring genetic testing men psychosocial issues prostate cancer genes |
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