A prospective study of the distribution of illness within the menstrual cycle

The cyclic physiological variations during the menstrual cycle are thought to be associated with change in emotional state, in susceptibility to illness, and in frequency of illness-related behavior. Variations in frequency of illness with the phases of the menstrual cycle were examined using data from a 3-year prospective study of social and psychological antecedents of viral illness in 94 student nurses. Reported illnesses, accidents, medical consultations, and hospital admissions were randomly distributed throughout the menstrual cycle. Subjects took more medication on the 1st day of menses than on any other day of the cycle; howeverreported menstrual symptoms were infrequent, with only 4% of the population reporting two or more such episodes. It was concluded that there was an increase in discomfort on the data of onset of menses which was self-medicated but not defined as illness. There was no discernible relationship of illness or disability to any phase of the cycle.This work was supported in part by Center for Oral Health Research (COHR) grant DEO 2116, and Oral Medicine Training Grant ST01-DE-77. The authors wish to recognize the contribution of Carol Ram, R. N., who was the administrator of this study and responsible for the collection and organization of the large bank of information from which the material for this paper was abstracted. Without her care, diligence, and intelligent management, this study could not have been completed. We also wish to acknowledge the consultive advice of Dr. Larry Laster, Director, Division of Biometrics, School of Dental Medicine, in choice of analytic techniques, and the help of Dr. Arthur Segal in the early stages of data analysis.